Arleen Sorkin, who played Calliope Jones on "Days of Our Lives," died. She was 67.

Sorkin was also the original voice of the DC Comics character Harley Quinn on "Batman: The Animated Series" in 1992.

A representative for Sorkin's husband, "Modern Family" co-creator and "Frasier" producer, Christopher Lloyd, confirmed her death to Fox News Digital.

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Days of Our Lives actress Arleen Sorkin holds American flag in portrait

Arleen Sorkin, original Harley Quinn voice actress, died. She was 67. (NBC)

Director James Gunn shared a heartfelt tribute to Sorkin on Instagram.

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"Rest in Peace, Arleen Sorkin, the incredibly talented original voice of Harley Quinn, who helped to create the character so many of us love. Love to her family and friends," he wrote.

Mark Hamill, who worked with Sorkin as the Joker on the "Batman" series, posted fond memories of Arleen on X, formerly known as Twitter.

Christopher Lloyd and wife Arleen Sorkin walk red carpet in black tie ensembles

Sorkin is survived by her husband, producer and writer Christopher Lloyd. (David Livingston)

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"Devastated to learn we've lost the brilliant Arleen Sorkin. Not just a wonderful talent, but a truly wonderful person," Hamill wrote. 

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"I'm grateful not only to have worked with her, but to have been her friend.Sending my heartfelt condolences to her family & loved ones."

Sorkin voiced the henchwoman character in a host of video games and animated classics, including "Batman: The Animated Series, "Justice League," "Gotham Girls" and "Batman: Arkham Asylum."

Arleen Sorkin chats on the phone wearing gold dress

Arleen Sorkin voiced Harley Quinn for decades between her starring role on "Days of Our Lives." (Ron Galella, Ltd.)

Margot Robbie stars as Harley Quinn on screen

Robbie has portrayed Quinn in three DC Comics films. (AP Images)

The Harley Quinn character has since skyrocketed to fame for DC Comics with Margot Robbie portraying the anti-hero in "Suicide Squad," "Birds of Prey" and Gunn's "The Suicide Squad."

Kaley Cuoco voices Quinn in the new animated series. Actress Tara Strong succeeded Sorkin as the voice of Harley Quinn.

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Her acting career began in the '80s with uncredited roles on "Saturday Night Live" and "Trading Places," before landing "Days of Our Lives" in 1984. 

Sorkin's character, Calliope Jones, wore many hats, and was just as eccentric as she was lovable. She received two daytime Emmy Award nominations for outstanding supporting actress in a drama series, in addition to four Soap Opera Digest awards. 

Harley Quinn animated drawing

Kaley Cuoco is the voice of Harley Quinn in a new DC Universe animated series. (Warner Bros. TV)

Arleen Sorkin wears elaborate ensemble as Calliope Jones on Days of Our Lives

Her character, Calliope Jones, first debuted in 1984, and starred in 427 episodes of the daytime soap. (NBC Universal)

She made a handful of appearances through the years, with her last performance on "Days" in May 2010.

Sorkin also served as the co-host of "America's Funniest People" in the early '90s with Dave Coulier, and had credits in "Duet," "Open House" and "Ted & Venus."

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Sorkin is survived by her husband and their two sons.